Spirituality addresses the need to give meaning to life events and is characterized by the relationship with oneself, others, and the universe. This article aims to provide an overview of the empirical knowledge, and the prevailing thoughts about spirituality in nursing and suggest perspectives for future directions. The literature review was conducted using the main databases, with thirty-six articles, published between 2008-2013, being selected. The themes covered include the definitions of spirituality, spiritual care, and spiritual well-being. Spirituality differs from (yet is not opposed to) religion and takes different forms in multicultural and secular societies. Cancer incites existential questions and impacts quality of life, and spiritual well-being is recognized as a good indicator of quality of life for people living with cancer. Professional caregivers are concerned about the needs and spiritual well-being of their patients and often consider interventions to address them. This article reflects the depth of thought and research in nursing and touches on both discipline-specific and interdisciplinary issues.