Nurses in clinical settings still do not fully rely on scientific knowledge to guide their practices and only rarely resort to the literature to find answers to their questions or clinical concerns. The sustainable implementation of projects that use knowledge founded on scientific evidence presents an important challenge that nursing research must address. The goal of this article is to present a strategy adopted by the Réseau infirmier, un partenaires de soins (RIUPS)  of the Université de Montréal (Québec). The strategy’s aim is to promote the optimal and long-lasting use of scientific knowledge in clinical settings and to incorporate the use of best practices based on scientific evidence into their operating procedure. First, we will present a brief overview of the evolution of nursing research and its impacts, followed by an inventory of the success factors of the use of scientific knowledge in practical settings, and finally the presentation of a model, Implementation Science, on which the RIUPS strategy relies for its projects. We also outline the network and one of its developments, the knowledge transfer portal and healthcare partners (PES).