Changing societal health care needs has led France’s Ministry of Health to rethink paramedical training courses. European harmonization was needed to set up this training as part of the French LMD system within a university framework. Based on this new paradigm, an educational reform consisting of a skills-based approach was implemented, leading to major modifications in the role of trainers. Consequently, training institutes for health care managers had to adapt their programs to this new learning concept. The main objective of this study was to identify the needs of trainers in charge of this new graduate nursing program. The secondary objective was to record their perceptions in order to recognize the positive or negative factors related to these changes. A questionnaire-style survey was conducted with 276 trainers from sixteen of the seventeen nursing schools of the Rhone-Alpes 2 region. One hundred and five trainers responded, corresponding to a rate of 38%. The majority of the respondents considered the new program as suitable, both for training and for the profession. The skills-based approach was seen as a factor of improvement. The learning to be developed is in line with reflective practice and the conception of symbolic situations. The study has allowed the needs of the trainers to be documented, in order to adapt their training. It has highlighted the importance of a referent trainer for the trainee, a major and valuable lever for change.