The specific contribution of caring to patient safety, particularly in rehabilitation, has not been explicitly clarified by previous studies. Considering the particular needs of patients in rehabilitation, it seems that a caring approach could have an important role in their safety. Inspired by the Quality-Caring Model© of Duffy and Hoskins (2003), the objective of this study, realized with twenty nurses who work in rehabilitation, was to understand the way their caring approach could contribute to their patients’ safety. The findings, obtained from semi-structured interviews performed within the qualitative phenomenological study, revealed that a caring approach leads to a beneficial transformation process, not only for patients, but also for nurses and the health care system, due to positive feedback. This transformational process notably constitutes the particular contribution of a caring approach to the physical, psychological, and psychosocial safety of patients.