The goal of this study was to examine perceptions of quality of life among women suffering from stage III or IV primary pulmonary hypertension and being treated with prostacyclin. This medication is a non-specific vasodilator with a short half-life. This was an exploratory, descriptive multiple-case study (3 cases). The interview guides were developed according to Zhan’s conceptual model of quality of life (1992). These helped in collecting qualitative data for content analysis. The results indicated that the three women were not satisfied with their quality of life, in terms of physical, psychological, social, and economic well-being, during the twelve weeks following start of treatment. Even though medical studies have shown a decrease in the mortality rate of individuals suffering from primary pulmonary hypertension within the first twelve weeks of prostacyclin treatment, this case study cannot conclude that the quality of life of these three women has improved. A longer data collection period, with a larger sample size of patients, is recommended for future research.