The purpose of the study on which this article is based was to assess the validity and reliability of a tool designed to measure quality of life. Sixty-four items applicable to both healthy subjects and dialysis patients were tested with graduate students (n = 88); six items related to dialysis were added, and the instrument was administered to dialysis patients (n = 37). Items were based on a literature review, which supported content validity. Correlations between the instrument and an overall satisfaction with life question of 0.75 (graduate students) and 0.65 (dialysis patients) supported criterion-related validity. Support for reliability was provided by test-retest correlations of 0.87 (graduate students) and 0.81 (dialysis patients) and Cronbach’s alphas of 0.93 (graduate students) and 0.90 (dialysis patients).