It is recognized that nurses regularly have to adapt their clinical practice in light of new scientific breakthroughs. However, changes in practice that are possible through the implementation of clinical projects can sometimes be time-consuming and difficult to achieve in health care settings, given the context of care or the profile of the clientele, the care organization, work organization, and so on. An algorithmic approach (i.e., sequence of actions) to support nurses in the evaluation of new nursing intervention projects, including other members of the interdisciplinary team, researchers, and patients and their relatives, has been developed. This algorithm considers the clinical environment in which the project will operationalize nursing interventions and involves five steps: 1) identification and description of a care problem to solve or a care practice to improve; 2) the development or adaptation of appropriate nursing intervention; 3) the choice of evaluation design for this nursing intervention; 4) testing of the intervention; and 5) implementation and reflection on the process.