Based on a survey of the literature in human and nursing sciences and illustrated with concrete research examples, we will identify promising research directions for mixed-method studies and present strategies for applying this type of research design to the evaluation of nursing interventions. This article provides three examples of mixed-method designs that utilize schematic representation for the evaluation of nursing interventions. Based on examples, the issues discussed are: (1) the sufficient significance of the research program, warranting investment in the required human and material resources; (2) the reasons for using qualitative and quantitative data simultaneously or sequentially; (3) the integration of qualitative and quantitative data when the participants are from different target populations; and (4) a presentation of the findings.